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Effect of platelet rich fibrin (PRF) in formation of tooth apex in cases of immature front teeth

To evaluate and compare apexogenesis induced by revascularization,with and without platelet-rich fibrin (PRF) in non-vital, immature anterior teeth â?? a pilot clinical study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2012/11/003086
Enrollment
20
Registered
2012-11-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Non-vital open apex immature anterior permanent teeth

Interventions

Intervention1: Apexogenesis with platelet rich fibrin: After control of intra canal infection by chemomechanical means indigenous stem cells residing in the periapical area of teeth being treated are

Sponsors

All India Institute of Medical Science
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: A)Patients having anterior maxillary non-vital, immature teeth with open apex with or without radiographic evidence of periapical lesion. B)Healthy patients with no systemic disorder

Exclusion criteria

Exclusion criteria: Systemic conditions that limit the invasive procedures and which can compromise the healing response

Design outcomes

Primary

MeasureTime frame
Complete control and resolution of clinical signs and symptoms such as pain, swelling, inflammation and restoration of function. Radiographic evidence of healing of periapical lesions showing disappearance or reduction in size of the lesion. Radiographic evaluation of dentinal wall thickening and elongation of root Timepoint: Follow up at 3,6 9,12 months

Secondary

MeasureTime frame
Seal of mineralized tissue at the root apices showing periapical healing, root lengthening, thickening of lateral dentinal walls, apical closureTimepoint: Follow up at 3,6 9,12 months

Countries

India

Contacts

Public ContactDr Naseem Shah

AIIMS

naseemys@gmail.com01126589304

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026