Health Condition 1: null- Moderate Mitral Stenosis with sinus rhythm
Conditions
Interventions
Intervention1: 1.Atenolol 50 mg once daily
2.Ivabradine 5 mg twice daily: Atenolol 50 mg once daily will be given for 6 weeks for one arm ang Ivabradine 5 mg twice daily will be given for second arm
Sponsors
Dr Sajeer Kalathingathodika
Eligibility
Inclusion criteria
Inclusion criteria: 1)Patients with Mitral stenosis with a mitral valve area calculated by planimetry and/or pressure half time method between 1 and 1.5 cm 2 2)Age between 18 years and 60 years. 3)Normal sinus rhythm. 4)NYHA functional class I-II
Exclusion criteria
Exclusion criteria: 1)More than mild mitral regurgitation and aortic stenosis or aortic regurgitation. 2)Echo estimated PA systolic pressure more than 50 mmHg. 3)NYHA functional class III-IV 4)COPD, Bronchial asthma. 5)Inability to perform exercise or contra indications for TMT. 6)Known coronary artery heart disease. 7)Baseline LV systolic dysfunction (EF less than 50 %). 8)Any known contraindications/hypersensitivity to beta blocker or Ivabradine 9)Patients not willing to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Change in the total duration of exercise in seconds from baseline TMT to post treatment TMT 2. Difference between the peak heart rate attained on baseline TMT and post treatment TMT Timepoint: 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in the LV myocardial performance index by tissue Doppler imaging from baseline to post treatment period. 2. Change in the Left atrial appendage filling and emptying velocities and tissue Doppler velocities by Transesophageal echocardiography from baseline to post treatment period Timepoint: 6 weeks | — |
Countries
India
Contacts
Public ContactDr sajeer Kalathingathodika
Dept.of Cardiology,Govt.Medical college, Kozhikode
Outcome results
None listed