None listed
Conditions
Interventions
Intervention1: Inactivated Poliovirus Vaccine: IPV given intramuscularly (0.5 ml) in children who are previously immunized with trivalent OPV six or more months in the past
Control Intervention1: Biva
Sponsors
Christian Medical College Vellore
Eligibility
Inclusion criteria
Inclusion criteria: Children who have received trivalent OPV vaccines in primary series and the last dose of any oral poliovirus vaccine 6 months or more remote in the past.
Exclusion criteria
Exclusion criteria: Child has a known digestive system defect. Child has history of chronic diarrhea (lasting more than 14 days). Child has major congenital anomalies. Child has known immunodeficiency Child has received a prior dose of IPV Child has received a dose of OPV in the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of children shedding type 1 polio virus.Timepoint: 7 days after bOPV challenge | — |
Secondary
| Measure | Time frame |
|---|---|
| geometric mean titre of poliovirus-specific IgA in saliva samplesTimepoint: 28 days after intervention;proportion of children shedding type 1 vaccine virus.Timepoint: 14 and 21 days after bOPV challenge;serum neutralizing antibody titre against poliovirusTimepoint: 28 days after intervention;viral copies per gram of stool estimated by RTPCRTimepoint: baseline, day 7, day 14, day 21 and day 28 post bOPV challenge | — |
Countries
India
Contacts
Public ContactJacob John
Christian Medical College
Outcome results
None listed