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Relation between inter-individual genetic variation and neonatal sepsis susceptibility, outcomes and inflammatory mediators level

Effect of gene polymorphism on inflammatory mediators, disease susceptibility and outcomes in neonatal sepsis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2012/09/002987
Enrollment
256
Registered
2012-09-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Neonatal sepsis

Interventions

None listed

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Ethnic group: Tamil speaking Dravidians 2. Age 3. Clinically diagnosed sepsis with at least two screening tests positive such as mESR, CRP, CBC. 4. No antibiotic treatment before blood sample collection

Exclusion criteria

Exclusion criteria: 1. Surgical procedures 2. Maternal history of infections, inflammations or antibiotic therapy before delivery 3. Apgar score 4. Presence of congenital malformations.

Design outcomes

Primary

MeasureTime frame
i. Minor allele frequency of selected SNPs in Tamil speaking Dravidian population will add knowledge to existing human genetic database. ii. Association of SNPs/CNVs of selected genes with neonatal sepsis can be used as genetic marker for prognosis of disease susceptibility and associated outcomes. iii. Association of SNPs/CNVs with inflammatory cytokines levels can be used to predetermine the severity of inflammation during sepsis progression.Timepoint: After genotyping—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactDr B Vishnu Bhat

JIPMER

drvishnubhat@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026