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Efficacy of dexmedetomidine as an adjuvant to ropivacaine in epidural anesthesia for total abdominal hysterectomy.

Comparative study of epidural ropivacaine with or without dexmedetomidine: a randomised controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2012/09/002960
Enrollment
100
Registered
2012-09-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Undergoing total abdominal hysterectomies under epidural anaesthesia

Interventions

Intervention1: ROPIVACAINE + DEXMEDETOMIDINE: 16 ml solution of 0.75% isobaric ropivacaine + 1.0 ug/kg of dexmedetomidine and normal saline to complete 1ml. single dose Control Intervention1: ROPIVACA

Sponsors

ESI PGIMSR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • ASA physical grading I and II • Age group of 40 years and above • Patient undergoing elective total abdominal hysterectomies

Exclusion criteria

Exclusion criteria: • Patient with morbid obesity (body weight > 100kg) • Uncontrolled hypertension • Uncontrolled diabetes mellitus • Impaired renal and hepatic function • History of :- • drugs and alcohol abuse • seizures disorder and psychiatric diseases • haematological disease, bleeding or coagulation test abnormalities, • allergy to local anaesthetics of the amide type • backache • Patient refusal to regional anaesthesia • Infection at local site • Pre-existing sensory or motor deficit • Deformity of spine

Design outcomes

Primary

MeasureTime frame
â?¢ Sensory block onset time â?¢ Motor block onset time â?¢ Maximum sensory level of anaesthesia â?¢ Maximum motor block intensity using Modified Bromage scale â?¢ Sensory block regression time â?¢ Motor block regression time â?¢ Complications (if any)Timepoint: time in minutes-0,1,2,3,4,5,10,15,20,25,30,35,40,50,60,70,80,90,100,110,120,130,140,150,160,170,180,190,200.—

Secondary

MeasureTime frame
â?¢ Level of sedation using Ramsay sedation scale â?¢ Hemodynamics â?¢ Post operative analgesia duration- VAS ( Visual Analogue score) VAS equal or greater than 4 or time of first analgesia request.(study ends) â?¢ Complications (if any)Timepoint: time in minutes-0,1,20,30,40,50,60,70,80,90,100,110,120,130,140,150,160,170,180,190,180,190,200,210,220,230,240,250,260,270,280,290,300,310,320,330,340,350,360.—

Countries

India

Contacts

Public ContactDR RAHUL POPLI

ESI PGIMSR HOSPITAL

suvidhasood@rediffmail.com09999302616

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026