Health Condition 1: null- Preterm neonates
Conditions
Interventions
Intervention1: Caffeine citrate: Loading dose 20mg/kg/day
Maintainence dose 5mg/kg/day
Will be given as IV till the neonate tolerates orally, then changed over to oral preparation.Drug will be contin
Sponsors
Indian Council of Medical Research ICMR
Eligibility
Inclusion criteria
Inclusion criteria: For study purpose, neonates will be divided into two groups i) ii) 29 to 34 completed weeks of gestation
Exclusion criteria
Exclusion criteria: 1. Dysmorphic features or congenital abnormalities likely to affect life or neurologic development 2. Parents declined consent 3. Neonates were unlikely to be available for long-term follow-up 4. Previously treated with a methylxanthine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.The main outcome variable will be the comparison of occurrence and frequency of apnoeic episodes in the two groups and failure of treatment defined as [13] - 50% reduction in apneic episodes, - use of IPPV 2. Cost-effectiveness analysis The secondary outcome measures will include duration of hospital stay, short term growth, adverse effects in two groups, gastric tolerance, need for invasive ventilation, effect on cardiac output and cerebral perfusion.Timepoint: Till discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures will include duration of hospital stay, short term growth, adverse effects in two groups, gastric tolerance, need for invasive ventilation, effect on cardiac output and cerebral perfusion.Timepoint: Till discharge | — |
Countries
India
Contacts
Public ContactDr Leslie Lewis
Kasturba Medical college hospital Manipal,Karnataka
Outcome results
None listed