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ICU patient response to tracheal suctioning with placebo, lignocaine or dexmedetomidine

Effect of intravenous lidocaine and dexmedetomidine on response to tracheal suctioning in intensive care unit patients - A prospective, randomised, double blinded, cross over study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2012/08/002898
Enrollment
40
Registered
2012-08-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ICU patients

Interventions

Intervention1: dexmedetomidine: 0.3 mcg/kg over 5 min IV 5 minutes prior to tracheal suctioning Intervention2: dexmedetomidine: 0.3 mcg/kg over 5 min IV 5 minutes prior to tracheal suctioning Interven

Sponsors

Kasturba Hospital KMC Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients that have a tracheal tube in situ in ICU

Exclusion criteria

Exclusion criteria: 1. Patients with known or suspected allergy to any of the study drugs (dexmedetomidine, lidocaine) 2. Patients with seizure disorder 3. Patients receiving neuromuscular blockade / with known neuromuscular disease 4. Patients who were hypotensive requiring more than one inotrope / vasopressor 5. Patients that were delirious or had disease condition that would confuse the behaviour assessment, such as decerebrate posturing

Design outcomes

Primary

MeasureTime frame
Numerical rating scale score Behavioural response score Haemodynamic fluctuations of 20% from baselineTimepoint: Baseline, at one minute interval for five minutes starting from the point of tracheal suctioning and at 10th and 15th minute following tracheal suctioning. Behavioural response and numerical rating was assessed just prior to tracheal suctioning and in the following minute after tracheal suctioning

Secondary

MeasureTime frame
Complications Arrhythmias, desaturation Timepoint: During study period, that is within 15 minutes after tracheal suctioning

Countries

India

Contacts

Public ContactUmesh Goneppanavar

KMC, Manipal, Manipal University, India

dr.swaroopa@rediffmail.com9886947695

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026