Health Condition 1: null- Septic Shock
Conditions
Interventions
Intervention1: Hydrocortisone: Inj Hydrocortisone 50 mg IV 6 hourly for 3 days
Control Intervention1: hydrocortisone: Inj Hydrocortisone 50 mg IV 6 hrly for 7 days
Sponsors
Post Graduate Institute of Medical Education and Research Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients aged more 18 years with diagnosis of refractory septic shock 2.Within 24 hour of diagnosis of sepsis/septic shock; and 3.Who give consent for participation in the study, are eligible for inclusion in the study
Exclusion criteria
Exclusion criteria: 1.Patients who are already receiving systemic corticosteroids at the time of screening. 2.Patients who require corticosteroids for longer duration such interstitial lung diseases, rheumatological diseases, exacerbation of asthma/COPD etc. 3.Immune compromised patients â?? cancers, HIV or prior history of corticosteroids use. 4.Patients who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome: Overall reversal of the shock. Secondary outcomes: Reversal of shock on day-3 and day-7, in-hospital mortality, day-28 mortality, duration vasopressors requirement, and complication rates such as hyper-glycaemia, super infection and neuromuscular weakness. Timepoint: Day 3 Day 7 At the time of discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| Reversal of shock on day-3 and day-7, in-hospital mortality, day-28 mortality, duration vasopressors requirement, and complication rates such as hyper-glycaemia, super infection and neuromuscular weakness. Timepoint: Day 3 Day 7 At the time of discharge | — |
Countries
India
Contacts
Public ContactVijay HADDA
Post Graduate Institute of Medical Education and Research, Chandigarh
Outcome results
None listed