Health Condition 1: null- Polycystic ovary syndrome
Conditions
Interventions
Intervention1: Metformin, pioglitazone, spironolactone: Tablet Metformin
750 mg per day orally increased to 1500mg per day orally if desired for 3 months
Tablet Pioglitazone
15 mg per day orally for
Sponsors
Dr Sunita J Ramanand
Eligibility
Inclusion criteria
Inclusion criteria: A) Clinical criteria: 1.oligomenorrhea or menstrual disturbances 3.S/S of Hyperandrogenism viz, acne, hirsuitism, alopecia. 4.Acanthosis nigricans. B) Hormonal criteria: 1.LH/FSH ratio >1.5 2.Serum Testosterone >1.1 ng/ml C) Abdominal USG: At least 10 follicles (2-8 mm in diameter) arranged peripherally around a dense core of ovarian stroma or scattered throughout an increased amount of stroma. Patient of PCOD having hypothyroidism will be treated with thyroxine. After achieving euthyroid states, patient will be included in the study.
Exclusion criteria
Exclusion criteria: 1) Systemic diseases- Renal, hepatic cardiac, RS , frank DM, hypertension , congenital adrenal hyperplasia, ,hyperprolactinemia, acromegaly, functional hypothalamic amenorrhea. 2) Past H/O lactic acidosis. 3) Patients undergoing IV contrast media study or surgical procedures. 4) BMI ( >30 mg/) kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regularisation of mensesTimepoint: 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in clinical features of PCOSTimepoint: 3 months | — |
Countries
India
Contacts
Public ContactDr Sunita J Ramanand
Govt. Medical College, Miraj
Outcome results
None listed