Health Condition 1: null- ICU Patients
Conditions
Interventions
Intervention1: (up to 1 microgram/kg dexmedetomidine or 0.05mg/kg midazolam): Each patient will receive study drug within 48hrs after intubation.
Control Intervention1: Dexmedetomidine: Dexmedetomidin
Sponsors
MEDANTA THE MEDICITY
Eligibility
Inclusion criteria
Inclusion criteria: •Consent by Legally Acceptable Representative •More than 18years of age. •In tuba ted and mechanically ventilated for less than 48 hours •Anticipated ventilation and sedation duration of at least 3 more days.
Exclusion criteria
Exclusion criteria: • Undergoing dialysis of any type • Pregnancy or lactation • Neuromuscular blockade other than for intubation • Epidural or spinal analgesia at the time of screening assessment • General anesthesia 24 hours prior to or planned at the time of the screening assessment. • Serious central nervous system pathology(acute stroke, uncontrolled seizures ,severe dementia) • Acute hepatitis or severe liver disease (Child-Pugh class C) • Unstable angina or acute myocardial infarction or left ventricular ejection fraction less than 30% • Heart rate less than 50/min • Second- or third degree heart block, or systolic blood pressure less than 90 mm Hg despite continuous infusions of 2 vasopressors before the start of study drug infusion. • History of microvascular flap surgical procedures cerebrovascular surgery or with a risk of vasospasm in the last three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare days of mechnical ventilation in patients receiving dexmedetomidine versus MedazolamTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢ Mortality in each group. â?¢ For each group the prevalence and duration of delirium, use of extra sedation and nursing assessments will also be reviewed. Sedation level and delirium will be assessed using the Richmond Agitation-Sedation Scale (RASS) and CAM(confusion assessment method)-ICU methods.Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactRajat Gupta
MEDANTA THE MEDICITY
Outcome results
None listed