Health Condition 1: null- Systemic Lupus Erythematosus
Conditions
Interventions
Intervention1: Vitamin D: 120000 Units of Vitamin D2 administered orally at baseline followed by 60000 Units once monthly for 3 months
Control Intervention1: Placebo: Placebo similar to Vitamin D 1200
Sponsors
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Female patients with systemic lupus erythematosus (SLE) fulfilling American College of Rheumatology classification criteria for SLE
Exclusion criteria
Exclusion criteria: a)Women less than 18 yrs age or more than 45 years b)Post menopausal women c)Presence of established cardiovascular disease d)Taking corticosteroids more than 15mg per day of Prednisolone or equivalent e)Not willing to take Vitamin D supplementation f)History of diabetes mellitus g)History of familial hypercholesterolemia h)Recent (less than 6 months) use of mega doses of vitamin D i)Pregnant j)Morbidly obese k)Past or current tobacco use or smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flow Mediated Dilatation (FMD) of Brachial arteryTimepoint: Baseline and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Intima Media Thickness (IMT)Timepoint: Baseline and 12 weeks | — |
Countries
India
Contacts
Public ContactDr Ranjan Gupta
Outcome results
None listed