Health Condition 1: null- patients with cirrhosis with no previous overt hepatic encephalopathy
Conditions
Interventions
Intervention1: probiotic: VSL#3, 110billion CFU each capsule per oral, three times a day, along with other usual medication for six months
Control Intervention1: placebo: patienst will be continued on
Sponsors
G B Pant Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Cirrhotic patients, age 18-75 years. No history of overt hepatic encephalopathy
Exclusion criteria
Exclusion criteria: Patients on lactulose therapy History of recent alcohol intake (in past 4 weeks) Recent infection or antibiotic use (in past 6 weeks) Patients on secondary prophylaxis for spontaneous bacterial peritonitis Recent G I bleeding Hepatocellular carcinoma Previous TIPS and shunt surgeries Use of psychotropic drugs which may affect psychometric tests Any neurologic disease such as Alzheimerâ??s disease, Parkinsonâ??s disease and nonhepatic metabolic encephalopathies Significant heart, respiratory or renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| development of overt hepatic encephalopathy in two groupsTimepoint: six months after recruitment of last patient in the study | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline psychometric test, critical flicker frequency (CFF), SIBO, oro-cecal transit time and blood ammonia level as predictor of development of hepatic encephalopathy.Timepoint: 6 month after recruitment of last patient | — |
Countries
India
Contacts
Public ContactDr B C Sharma
G B Pant Hospital
Outcome results
None listed