Health Condition 1: null- Patient with metastatic breast cancer at first presentation.
Conditions
Interventions
Intervention1: Locoregional Treatment (LRT): Locoregional Treatment group patients will receive standard loco-regional (LRT)treatment i.e. surgery (modified radical mastectomy (MRM)/ Simple SMAC/BCT)
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Metastatic breast cancer patients with expected survival of at least one year
Exclusion criteria
Exclusion criteria: 1.Patients who are not fit to receive anthracycline / taxane based chemotherapy. 2.More than two visceral organ involvements. 3.Multiple liver metastases with deranged liver function tests (SGOT/SGPT more than four times the upper normal limit). 4.Locally static or progressive disease or systemically progressive disease as shown by repeat staging investigations guided by worsening symptoms. 5.Ulceration/ fungation/ bleeding after completion of chemotherapy, which mandates surgery. 6.Expected survival of less than six months after completion of chemotherapy. 7.Unfit for anaesthesia due to metastatic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To assess impact of loco-regional treatment on survival in metastatic breast cancer patientsTimepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess impact of loco-regional treatment on levels of VEGF, bFGF, Angiostatin, Endostatin in blood of metastatic breast cancer patients. Timepoint: 5 years | — |
Countries
India
Contacts
Public ContactMs Rohini Hawaldar
Tata Memorial Hospital
Outcome results
None listed