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Study to compare the effect of a synthetic bone graft material alone and in combination with a component of blood (platelet membrane) in bony defects associated with gum diseases

A clinical evaluation of efficacy of bone graft material (Beta -tricalcium phosphate + hydroxyapatite) alone and in combination with platelet rich fibrin membrane in treatment of periodontal intrabony defects

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2012/07/002793
Enrollment
20
Registered
2012-07-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Periodontitis (osseous defects)

Interventions

Intervention1: Group B: Patients in test group with intrabony defects will be treated with bone graft material (Beta - tricalcium phosphate + hydroxyapatite) in combination with Platelet Rich Fibrin m

Sponsors

SMBT DENTAL COLLEGE HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Intrabony defects in maxillary and mandibular arch 2. Patients with two or more intrabony defects (Isolateral/contralateral) as well as isolated intrabony defects 3. Intrabony defects (IBD)greater than or equal to 3 mm deep [distance between alveolar crest and base of the defect on intraoral periapical radiograph (IOPA)] along with an interproximal probing depth (PD) greater than or equal to 5 mm following phase I therapy 4. Absence of overt clinical inflammation at the time of surgery 5. Adequate amounts of interdental soft tissues 6. Absence of any local anatomical limitations 7. Patient willing for surgery and ready to give written consent

Exclusion criteria

Exclusion criteria: 1.Patients with systemic illness known to affect the outcomes of periodontal therapy, such as diabetes mellitus, cardiac diseases, platelet count less than 200,000/mm cube, or immunocompromised (e.g., HIV individuals) patients taking medications, such as corticosteroids. 2.Individuals allergic to medications 3.Pregnant or lactating women 4.Patients using tobacco in any form 5.Individuals with unacceptable oral hygiene (plaque index [PI] greater than 1.5).

Design outcomes

Primary

MeasureTime frame
Probing depth, Clinical attachment levelTimepoint: 4 months

Secondary

MeasureTime frame
Radiographic evaluation with the help of image analysis softwareTimepoint: 4 months

Countries

India

Contacts

Public ContactPooja S Malpani

S M B T Dental College and Hospital, Sangamner

drom94@yahoo.com9321019946

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026