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Intravenous clonidine for controlled hypotension in Functional Endoscopic Sinus Surgery

Double Blind Randomised placebo controlled trial to evaluate intravenous clonidine as a hypotensive agent in Functional Endoscopic Sinus surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2012/07/002790
Enrollment
60
Registered
2012-07-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Functional endoscopic sinus surgery

Interventions

Intervention1: Clonidine: 3 microgrammes per kilogram body weight diluted to 5 ml with water for injection. This was injected as a stat dose 30 minutes prior to induction of anaesthesia Control Interv

Sponsors

Christian Medical College Fluid Research Fund
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2

Exclusion criteria

Exclusion criteria: 1. Hypertension 2. Diabetes with autonomic neuropathy 3. Treatment with clonidine, beta blocker or calcium channel blocker 4. Pregnant mothers 5. Age 65 years

Design outcomes

Primary

MeasureTime frame
Achievement of target mean blood pressure of 55-60 mmHgTimepoint: Intra-operative period—

Secondary

MeasureTime frame
1. Blood loss 2. Dry surgical field 3. Sedation 4. Pain relief 5. Hypotension 6. BradycardiaTimepoint: 1. Intra-operative period 2. Intra-operative perod 3. Reversal of anaesthesia and recovery room 4. Post-operative period 5. Peri-operative period 6. Peri-operative period—

Countries

India

Contacts

Public ContactDr Subramani K

Christian Medical College

ksubramani9@hotmail.com04162282693

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026