Health Condition 1: null- NORMOGONADOTROPHIC OLIGOZOOSPERMIA
Conditions
Interventions
Intervention1: CLOMIPHENE CITRATE: CLOMIPHENE CITRATE 25 MG DAILY-- AFTER 2 WEEKS DOSE MAY BE INCREASED TO 50 MG DAILY DEPENDING ON THE RESPONSE OF FSH AND TESTOSTERONE LEVELS IN BLOOD AND THEN CONTIN
Sponsors
DR SUDHINDRA MOHAN BHATTACHARYA
Eligibility
Inclusion criteria
Inclusion criteria: HUSBANDS OF INFERTILE COUPLES WILL UNDERGO SEMEN ANALYSIS. THOSE WITH OLIGOZOOSPERMIA (SPERM COUNT LESS THAN 20 MILLION/ML)WILL UNDERGO SERUM FSH AND TESTOSTERONE TESTED. IF FSH VALUE IS NORMAL, THEN CLOMIPHENE CITRATE 25 MG WILL BE GIVEN DAILY ORALLY. AFTER 2 WEEKS FSH AND TESTOSTERONE LEVELS WILL BE MEASURED. IF RESPONSE IS OPTIMUM, THEN IT WILL BE CONTINUED FOR AT LEAST 3 MONTHS FOR FINAL SEMEN ANALYSIS. IF RESPONSE IS SUBOPTIMUM, DOSE OF CLOMIPHENE CITRATE WILL BE INCREASED TO 50 MG DAILY.
Exclusion criteria
Exclusion criteria: THOSE WITH PRIMARY SPERMATOGONIC FAILURE; THOSE WITH HERNIA, HYDROCOELE, KNOWN VARICOCOELE, PAST HISTORY OF EPIDIDYMO-ORCHITIS; THOSE SHOWING INADEQUATE RESPONSE TO 2 WEEKS OF CLOMIPHENE CITRATE 50 DAILY TAKEN FOR AT LEAST 2 WEEKS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CHANGES IN DIFFERENT SEMEN PARAMETERS- NAMELY, VOLUME,CONCENTRATION, MOTILITY, RAPID PROGRESSIVE MOTILITY, HOS TEST (HYPO-OSMOTIC SWELLING TEST),MORPHOLOGY, DNA- INTEGRITY TEST (BY ACRIDINE ORANGE STAINING TEST)Timepoint: CHANGES IN DIFFERENT SEMEN PARAMETERS AFTER 3 MONTHS OF TREATMENT | — |
Secondary
| Measure | Time frame |
|---|---|
| ANY COUPLE SPONTANEOUSLY CONCEIVING WHILE THE HUSBAND IS ON TREATMENT WITHIN THE STIPULATED 3 MONTHS TIME PERIOD.Timepoint: 3 MONTHS. | — |
Countries
India
Contacts
Public ContactSUDHINDRA MOHAN BHATTACHARYA
S.C.DAS MEMORIAL MEDICAL AND RESEARCH CENTER; KPC MEDICAL COLLEGE. KOLKATA
Outcome results
None listed