Health Condition 1: null- Patients undergoing ERCP under monitored anaesthesia care at SGPGI, Lucknow
Conditions
Interventions
Intervention1: Clonidine (4 mck/kg): Route of administration: Oral
Dose 4 mcg/kg single dose
Half life 12 hours
Control Intervention1: Atenolol 25mg: Route of administration: oral
Dose 25mg single do
Sponsors
SGPGI
Eligibility
Inclusion criteria
Inclusion criteria: > 18yrs, Undergoing elective ERCP (diagnostic or therapeutic) under monitored anaesthesia care
Exclusion criteria
Exclusion criteria: Consent not given Patients already on Atenolol or Clonidine or on Cardiac Drugs. Heart rate less 60 per min or Blood Pressure less than 100mgHG systolic. Pregnant patients. Emergency procedure. ASA more than or equal to 4 patients Patients requiring airway intervention or general anaesthesia. Expected duration less than 30min or more than 2hours. Patients with history of drug abuse or allergy to the drugs to be used.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effectiveness of Atenolol and Clonidine premedication in preventing hemodynamic stress and myocardial injury in patients undergoing ERCP under sedation.Timepoint: During procedure and 24 hours after procedure. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To study the occurrence of adverse effects during ERCP. 2.To study the hemodynamic response to Buscopan administration. 3.To study the dose requirement of Propofol during the procedure and the effect of Atenolol and Clonidine premedication on it. 4.To assess the patient and operator satisfaction with procedures under sedation in our institution. 5.To evaluate the time of awakening and discharge to ward. Timepoint: during procedure and 24 hours after the procedure | — |
Countries
India
Contacts
Public ContactDr Devendra Gupta
SGPGI, Lucknow
Outcome results
None listed