FindTrial
Sign In

Comparison between IV dexmedetomidine (to reduce pain and increase in heart rate, blood pressure) and local lignocaine infiltration to reduce hemodynamic response (increase in heart rate,blood pressure) to skull pin application (to stabilize head) during neurosurgery

Comparison between intravenous dexmedetomidine and lignocaine infiltration to attenuate the haemodynamic response to skull pin head-holder application during craniotomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2012/04/002595
Enrollment
50
Registered
2012-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- AGED BETWEEN 18-70 YEARS, BELONGING TO AMERICAN SOCIETY OF ANESTHESIOLOGISTS PHYSICAL STATUS 1 AND 2, SCHEDULED FOR ELECTIVE CRANIOTOMY UNDER GENERAL ANESTHESIA

Interventions

Intervention1: INTRAVENOUS DEXMEDETOMIDINE: IV DEXMEDETOMIDINE 1mcg/kg is given as infusion over 10 minutes soon after recording the baseline hemodynamic parameters in the operating room Control Inter

Sponsors

KASTURBA HOSPITAL KASTURBA MEDICAL COLLEGE MANIPAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective craniotomy in supine or lateral position under general anaesthesia. 2. American Society of Anesthesiologists Physical Status (ASAPS) 1or 2 3. Age between 18 to 70 years

Exclusion criteria

Exclusion criteria: 1. Hypertension 2. Ischaemic heart disease 3. 2nd or 3rd degree heart block 4. Pregnancy or lactation 5. Signs and symptoms of raised intracranial pressure 6. Head injury 7. Previous craniotomy

Design outcomes

Primary

MeasureTime frame
HEART RATE (less than 40 beats per minute and 30% increase)AND MEAN ARTERIAL PRESSURE (30% change) RESPONSE TO SKULL PIN APPLICATIONTimepoint: 1, 2, 3, 4, 5, 10 AND 15 minutes after pin application—

Secondary

MeasureTime frame
entropy valuesTimepoint: 1,2,3,4,5,10,15 minutes after pin application—

Countries

India

Contacts

Public ContactKRISHNA H M

KASTURBA MEDICAL COLLEGE, MANIPAL

hmkrishna20032002@gmail.com9448983314

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026