Health Condition 1: null- Knee osteoarthritis
Conditions
Interventions
Intervention1: Leech therapy with Qurs-e-mafasil (unani formulation): Leech therapy 2 leeches per knee joint once in a week for 4 weeks (5 applications) along with qurs-e-mafasil 500 mg 2 BD for 28 da
Sponsors
Jamia Hamdard
Eligibility
Inclusion criteria
Inclusion criteria: Individuals > 40 yrs, either sex Diagnosed as OA of the knee of at least 6 months duration fulfilling American College of Rheumatology criteria Knee pain VAS- pain after walking 1,524 cm (50 feet) in a flat surface >30 mm and Kellgren-Lawrence Radiographic Grading Scale of Osteoarthritis of the Tibiofemoral Joint Grade 1â?? 3 Patients who were willing to discontinue all NSAIDs or other analgesic medication taken for any condition Patients who had given their written informed consent & agreed to follow the protocol voluntarily
Exclusion criteria
Exclusion criteria: Pregnancy and Lactation Anemia ( Diabetes mellitus Patients who were on steroid drug therapy History of surgery of the joint involved, Tidal lavage or arthroscopy of either knee within the past 12 months Hypersensitivity/ allergy to food &/ drug or leech Intra-articular (IA) corticosteroid injection of either knee within a 3 month interval immediately prior to baseline screening Acute medical or surgical conditions which could affect the outcome of the study such as cardiac, renal, hepatic diseases. Patients who were using anti-coagulants (coumadin, heparin, aspirin >325 mg per day). Patients were not willing to be randomized Ongoing use of prohibited medication including NSAID, other oral analgesic, muscle relaxant, or low-dose antidepressant for any chronic pain management Concomitant skin disease at the application site History of alcohol or Drug abuse, excessive smoking (more than 10 cigarettes/day) Established/ diagnosed neurological or psychiatric disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale (VAS), Knee injury and osteoarthritis outcome score (KOOS), active & passive range of motion (ROM), 15-meter walking time, knee circumference, Kellgren-Lawrence radiographic grading scale. Arthritic profile, CBC with ESR, LFT, KFT, Bleeding time, Clotting time and Prothrombin time,Timepoint: 28th day (4th week) | — |
Secondary
| Measure | Time frame |
|---|---|
| visual analogue scale, Knee injury and osteoarthritis outcome score (KOOS), active range of motion (AROM) & passive range of motion (PROM), 15-meter walking time, knee circumferenceTimepoint: 2, 6, 8 weeks | — |
Countries
India
Contacts
Public ContactMohamed Suhood Mohamed Shiffa
Jamia Hamdard
Outcome results
None listed