Health Condition 1: O141- Severe pre-eclampsia Health Condition 2: null- Women with Severe Pre-eclampsia
Conditions
Interventions
Intervention1: Magnesium Sulphate: â?¢Group A: Dhaka Regime
o loading dose of 10 gm of magnesium sulphate
4 gm as 20% given intravenously over 10- 15 minutes and 6gm as 50 % solution, 3gm intramuscularly in each buttock. A maintenance dose of 2.5 gm of magnesium sulphate will be given intramuscularly
4 gm as 20% given intravenously over 10- 15 minutes and 6gm as 50 % solution, 3gm intramuscularly in each buttock
with no further doses of magnesium sulphate.
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: •Any pregnant woman with Severe Pre- eclampsia as per the ACOG Criteria: o Systolic blood pressure of 160 mm Hg or higher or diastolic blood pressure of 110 mm Hg or higher on two occasions at least 6 hours apart. o Proteinuria of 5 gm or higher in a 24-hour urine specimen or 3+ or greater on two random urine samples collected at least 4 hours apart. o Oliguria of less than 500 ml in 24 hours. o Cerebral or visual disturbances o Pulmonary edema or cyanosis o Epigastric or right upper-quadrant pain o Impaired liver function o Thrombocytopenia o Fetal growth restriction
Exclusion criteria
Exclusion criteria: o Multiple Pregnancy o Platelet count o Plasma creatinine value >= 2mg/dl o Comatose patients o Deranged coagulation profile o Known case of myasthenia gravis o Known case of seizure disorder o Patients with Eclampsia (defined as presence of new-onset grand mal seizures in a woman with preeclampsia). o Hypersensitivity to Magnesium. o Women who have received have received magnesium sulphate therapy before being referred.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of Eclampsia defined as new-onset grand mal seizures in a woman with preeclampsiaTimepoint: Within 48 hours postpartum | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal Death o Serious Maternal Morbidity such Renal Failure, Liver Failure, Pulmonary Edema, Cerebral hemorrhage, Coagulopathy, Cardiac arrest o Complications of labor and delivery such as Placental Abruption, Incidence of Cesarean Section, Retained Placenta, Blood Transfusion o Side Effects due to magnesium sulphate such as Nausea or vomiting, abscess, Respiratory Depression oFetal Complications Still birth, APGAR Score At 5 minutes, Neonatal ICU admission, neonatal Loss Timepoint: Within 48 hours postpartum | — |
Countries
India
Contacts
Public ContactAnish Keepanasseril
JIPMER
Outcome results
None listed