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"A study to test the efficacy of local application of epidermal growth factor in the treatment of non-healing ear drum perforations"

â?? THE EFFECT OF EPIDERMAL GROWTH FACTOR ON NON HEALING TYMPANIC MEMBRANE PERFORATIONS: A COMPARITIVE STUDYâ??

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2012/03/002493
Enrollment
60
Registered
2012-03-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- CHRONIC SUPPURATIVE OTITIS MEDIA TRAUMATIC PERFORATION OF TYMPANIC MEMBRANE

Interventions

Intervention1: EPIDERMAL GROWTH FACTOR: Epidermal growth factor (EGF) is an important modulator of cell growth and its role in normal wound healing is well documented. Epidermal growth factor receptor

Sponsors

KARNATAKA INSTITUTE OF MEDICAL SCIENCES
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects having inactive/quiescent CSOM with non healing small (less than 5 mm) size perforation in the pars tensa . 2. Small (less than 5 mm size) traumatic perforation, not healing for at least one month. 3. Age more than 14 yrs. 4. No active predisposing disease foci in nose or throat.

Exclusion criteria

Exclusion criteria: 1. Large central perforation size more than 5 mm 2. Pars flacida perforation 3. Actively discharging ear 4. TB otitis media 5. ASOM 6. Fresh traumatic perforation. 7. Marginal perforation. 8. Subtotal perforation.

Design outcomes

Primary

MeasureTime frame
CLOSURE OF TYMPANIC MEMBRANE PERFORATIONS AND IMPROVEMENT IN HEARINGTimepoint: 1st ,2nd and 4th month after the procedure—

Secondary

MeasureTime frame
ANY COMPLICATIONS LIKE INCREASE IN SIZE OF PERFORATIONS,CHOLESTATOMA FORMATIONS ,.CHRONIC DISCAHRGING EARTimepoint: 1st ,2nd and 4th month after the procedure—

Countries

India

Contacts

Public ContactDR VIKRAM BHAT

KARNATAKA INSTITUTE OF MEDICAL SCIENCES, HUBLI, KARNATAKA STATE.

vikram.ent@gmail.com9448658213

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026