Health Condition 1: null- Stage I Hypertension JNC7 Criteria
Conditions
Interventions
Intervention1: Nebivolol: 5mg Once Daily for 15 days
Control Intervention1: none: nil
Sponsors
Nizams Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: ) Ambulatory, Male and Female Volunteers between 18-55 years of age with a Body Mass Index (BMI) of approximately 18-30 kg/m2 diagnosed with stageI hypertension Essential Hypertension of greater than at least 1 month duration. 4) Stage 1 Hypertension with Systolic BP 140-159 or Diastolic BP 90-99 (JNC-7 Criteria) of greater than at least 1 month duration
Exclusion criteria
Exclusion criteria: 1) Secondary Hypertension. 2) Uncontrolled Hypertension. 3) History of Hypersensitivity to Beta Blockers or any component of the product. 4) Patients With Severe Bradycardia, Heart Block, Cardiogenic Shock, Decompensated Heart Failure, Sick Sinus Syndrome. 5) Females who are Pregnant or Lactating or planning to become Pregnant. 8) Subjects on Fluoxetine, Nicardipine, Cimetidine, Non- Dihydropyridine CCB?s and other CYP2D6 Inhibitors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Central Aortic Pressures Timepoint: At baseline and End of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Brachial blood pressure Carotid-Femoral pulse wave velocity Reflection Index & Stiffness index Ambulatory blood Pressure Timepoint: At baseline and end of treatment | — |
Countries
India
Contacts
Public ContactDrRadhikaSoanker
Nizams Institute of Medical Sciences
Outcome results
None listed