Health Condition 1: Z77-Z99- Persons with potential health hazards related to family and personal history and certain conditions influencing health status
Conditions
Interventions
Intervention1: Aspirin: Low dose (150 mg)aspirin (acetylsalicylic acid) administered once daily for a period of 90 days.
Control Intervention1: Placebo: Placebo Tablets. Administered once daily for a
Sponsors
AOSpine Asia Pacific
Eligibility
Inclusion criteria
Inclusion criteria: a)Patients with acute spinal cord injury (i.e those with neurological deficit) presenting within 7 days of injury. b)Age above 18 years and below 60 years of age.
Exclusion criteria
Exclusion criteria: a)Cases of spinal trauma without spinal cord injury i.e. patients without neurological deficit. b)Cases presenting after 7 days of injury. c)Age below 18 years or above 60 years. d)Pregnant patients. e)Past history of radiologically documented venous thromboembolism f)Cases with a beneficial and clear indication of aspirin use e.g. patients with Myocardial Infarction or those requiring long term antiplatelet therapy. g)Anticipated non-availability of follow-up and failure or inability to give informed consent. h)Cases with contraindications to aspirin use, viz. history of acid peptic disease or gastro-esophageal reflux disesase, history of bleeding disorders, hypoprothrombinemia or haemophilias, chronic renal disease or chronic liver disease, history of allergy to aspirin and history of bronchial asthma. i)Cases who have taken aspirin within 48 hours prior to admission j)Patients on long term treatment with NSAIDs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a) Reduction in the risk of venous thromboembolism events and/or b) all cause mortality at the end of ninety days.Timepoint: 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurence of major bleeds (i.e. those necessitating blood transfusion) and minor bleeds (i.e. those not necessitating blood transfusion)and other complications specifically related to aspirin.Timepoint: 90 days | — |
Countries
India
Contacts
Public ContactDR SIDDHARTHA SHARMA
GOVERNMENT MEDICAL COLLEGE AND ASSOCIATED HOSPITALS, JAMMU
Outcome results
None listed