Health Condition 1: null- Asthma
Conditions
Interventions
Intervention1: Doxycycline: Doxycycline 100mg used orally twice daily after one hr of taking meals. The drug will be used for at least 6 months
if improved may be continued even beyond one year.
Control Intervention1: No comparator: Since it is a single arm trial no comparator drug/agent was used.
Sponsors
Institute of Pulmocare Research
Institute of Pulmocare and Research
Eligibility
Inclusion criteria
Inclusion criteria: a) Willing to participate in the trial. b) History of SOB with wheeze with variability (seasonal, diurnal, others) with h/o spontaneous recovery (wellbeing) or relief from oral or inhaled bronchodialators with or without family history of diagnosed or suggestive asthma and / or allergic rhinitis with documentation of airflow limitation with or without reversibility. c) Thus both certain and possible cases of chronic asthmatics will be incorporated.
Exclusion criteria
Exclusion criteria: i) Age 13 yrs and75yrs ii) Unwillingly for informed written consent iii) H/o doxycycline intolerance iv) Very sick patient unable for follow up. v) Significant Co-morbidity â?? that can affect the spirometric performance or the synptomatology. vi) FEV160% of predicted value vii) Clinically obvious anemia and HB% if measured 7.0 gm% viii) Pregnancy and lactation ix) Exacerbation in last 6 weeks. x) No other obvious lung disease as assessed by the physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in both pre and post FEVITimepoint: preferably at least 6 months of continuation of doxycycline therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Parthasarathi Bhattacharyya
Institute of Pulmocare & Research
Outcome results
None listed