Health Condition 1: null- Chronic rhinosinusitis
Conditions
Interventions
Intervention1: Homoeopathic medicines
Acid Nit.
Aconitinum
Allium Cepa
Antimodicum Crude
Apis Mel
Arsenicum Alb
Arsenicum Iod
Aurum Metallicum
Belladonna
Berbaris Vulgaris
Byronia Alb
Calcarea Carboni
Sponsors
Central Council for Research in Homoeopathy
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age group between 18-60 years from both gender. 2.Patients suffering from chronic rhinosinusitis (with or without nasal polyps) as defined in European Position paper on rhinosinusitis and polyps 2007.i.e. -Presence of two or more symptoms one of which should be nasal blockage/ obstruction/congestion or nasal discharge (anterior/posterior nasal drip): - facial pain/pressure - reduction or loss of smell for >12 weeks with validation by interview. 3 Written informed consent 4 Patients who can act in accordance with the protocol
Exclusion criteria
Exclusion criteria: 1Patients who are not adequately symptomatic. 2Patients with serious underlying medical condition (eg. Severe renal or hepatic disease) 3Patients with history of malignancy. 4Patients taken any medication prior to entry into the study (can be enrolled after wash out period of 15 days). 5Patients taken topical steroids within 4 weeks before the study therapy (can be enrolled after wash out period of 1 month) 6 Atrophic rhinitis 7Complications of chronic rhinosinusitis 8Significant psychological problems 9Pregnant women 10 Lactating mother 11Do not give informed consent. 12H/o of underlying immunodeficiencies, cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, diabetes mellitus, neoplasia or fungal sinusitis. 13Systemic diseases preventing participation in the study and medical and/or surgical treatments influencing the study. 14 No prior paranasal sinus, nose surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢To assess the improvement in the TSS over 3 months with area under the curve. â?¢ The changes from baseline to 3 months in the Sinus Nasal Outcome Test 22 (SNOT-22) Timepoint: â?¢To assess the improvement in the TSS over 3 months with area under the curve. â?¢ The changes from baseline to 3 months in the Sinus Nasal Outcome Test 22 (SNOT-22) | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢Change in SNOT-22 at 6 months â?¢Objective clinical and laboratory outcome measures include changes in nasal endoscopy (at 3 months, 6 months) and CT scan (at 3 months). â?¢Changes in absolute eosinophilic count (AEC) at 3 months. â?¢No. of AE-CRS during observation period which includes endoscopic findings. Number of AE-CRS (FDI) in between groups. â?¢Changes in global assessment by patient and physician at 3 months and 6 months. Timepoint: 3 months, 6 months | — |
Countries
India
Contacts
Public ContactDr Praveen Oberai
Central Council for Research in Homoeopathy
Outcome results
None listed