Homoeopathy as as add on treatment for severe Leptospirosis patients on conventional care

A single-blind, open randomized, placebo-controlled trial of add-on homoeopathic therapy in patients of severe leptospirosis on conventional care

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2012/01/002316

Enrollment

Registered

2012-01-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Severe Leptospirosis

Interventions

Intervention1: Conventional Care + Homoeopathic medicine 1.Aconitinum 2. Arnica Montana 3. Arsenicum album 4. Baptisia Tinctoria 5. Belladonna 6. Bryonia 7. China 8. Crotalus Horridus 9. Echin

Eligibility

Inclusion criteria

Inclusion criteria: Patients meet all of the following criteria will be eligible for study participation: -Patients of either sex, age group above 12 years, presenting to study physician with signs/symptoms of severe Leptospirosis. -Score 26 or more on faines criteria (a score between 20 and 25 suggests as possible but uncorfirmed diagnosis). -Written informed consent. -Presumptive diagnosis of leptospirosis with Lateral flow rapid test positive on two separate samples drawn on same day/ Confirmatory diagnosis through MAT (Single High titre /Rising titre (Paired sera)

Exclusion criteria

Exclusion criteria: Patients meeting any of the following criteria will be excluded: -Patients with clinical history of mixed presentation, arising suspicion of a mixed infection like malaria, dengue haemorrhgic fever etc. -Anuria on admission. -Confusion, stupor or coma. -Immune compromised or with other clinically active illness (Diabetes mellitus, cardiac ailments etc.). -Patients requiring intensive care unit. -Pregnant women. -Lactating mother.

Design outcomes

Primary

Measure	Time frame
reduction in the mortalityTimepoint: 1 month	—

Secondary

Measure	Time frame
â?¢The time to resolution of fever â?¢Duration of headache â?¢Duration of myalgia â?¢Duration of vomiting â?¢Suffusion of conjunctiva â?¢Normalization of the altered liver & kidney function as evident from laboratory reports. â?¢Total duration of hospitalization â?¢Institutional cost of therapy â?¢Days to normal work â?¢Adverse drug reaction Timepoint: 30 days , 3months	—

Countries

India

Contacts

Public ContactDr Praveen Oberai

Central Council for Research in Homoeopathy

oberai.praveen@gmail.com01128525749

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026