Health Condition 1: E119- Type 2 diabetes mellitus without complications Health Condition 2: null- Uncontrolled Type 2 Diabetes
Conditions
Interventions
Intervention1: Tab Bromocriptine mesylate 0.8 mg quick release formulaton: Bromociptine tablet 0.8 mg (1 tablet) daily will be given in first week, followed by 1.6 mg (2 tablets) in 2nd week, later 2.
Sponsors
Smt Kashibai Navale Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Age between 30 to 70 years Sex: Male or Non-lactating female HbA1 more than 8 Type 2 Diabetic patient on Sulphonylureas or Metformin not responding adequately
Exclusion criteria
Exclusion criteria: Age less than 30 yrs. Pregnancy Lactating mother Patient with Insulin dependent Diabetes Mellites Patient who is taking oral antidiabetic drugs other than Sulphonyureas and Metformin Severe and Complicated diabetes Patient with IHD Patients having renal or hepatic dysfunction Patient of Parkinsonism, syncopal migraine Patient who is taking Salicylates, Sulfonamides, Chloramphenicol, Probenecid, Phenithiazines, Butyrophenones, Thioxanthenes,Metoclopramide Strong Inhibitors/Inducers/ Substrates of CYP 3A4 Inhibitors -sodium valproate, erythromycin, Fluroquinolones except ofloxacin, verapamil, diltiazem, propoxyphene, allopurinol, MAO inhibitors, disulfiram, tolbutamide, metronidazole,captopril, enalpril, carbidopa Inducers :Phenobarbitone, phenytoin, carbamazepine, ethanol, clofibrate, griseofulvin, Rifampcin, pyridoxine Substrates: barbiturates, warfarin,theophylline, paracetamol, ascorbic acid, dextropropoxyphene, tolbutamide, diazepam, vit D, oral contraceptives, antidepressants, quinidine, terfanidine,phenytion, carbamazepine, morphine, pethidine, HIV positive patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare glycemic control measured by fasting and postmeal levels of HbA1c between Bromocriptine and Pioglitazone To compare fasting and postmeal blood sugar level between Bromocriptine and Pioglitazone Fasting and postmeal serum insulin level between Bromocriptine and Pioglitazone To comapre adverse effects between Bromocriptine and Pioglitazone Timepoint: baseline 1 2 3 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare Serum LDL, HDL, VLDL, Triglycerides, Total Cholesterol between Bromocriptine and Pioglitazone To compare blood pressure between Bromocriptine and Pioglitazone To compare weight reduction between Bromocriptine and Pioglitazone Timepoint: baseline 1 2 3 6 months | — |
Countries
India
Contacts
Public ContactDr Yogendra N Keche
Smt Kashibai Navale Medical College and Hospital
Outcome results
None listed