Skip to content

A clinical trial to determine the optimum dose of radioiodine for treating the left over Thyroid cancer cells after surgery

Determination of optimum administered activity of radionuclide (I131) for remnant ablation in patients with differentiated thyroid cancer: A randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2011/12/002291
Enrollment
422
Registered
2011-12-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Differentiated Thyroid Cancer

Interventions

Intervention1: Radioiodine 25 mci: single dose, injectible Intervention2: Radioiodine,50 mci: single dose, injectible Control Intervention1: Radioiodine 100mci: 100 mCi single dose, injectible

Sponsors

All India Institute of Medical Sciences
Lead Sponsor
Indian Council of Medical Research
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients with disease confirmed to be limited to the thyroid bed only by clinical, radiological, per-operative, and post-surgical 131I scintigraphic examination and having no evidence of extra thyroidal or distant metastases at the time of radioiodine treatment. Patients with tumor size (T1-3)

Exclusion criteria

Exclusion criteria: Patients with less than total/near total thyroidectomy. T4 tumor size. Aggressive histology such as tall cell and columnar cell papillary carcinoma, hurthle cell carcinoma and poorly differentiated carcinoma. If at any time, extra thyroidal disease in the form of either nodal or distant metastases was detected before the first-dose outcome. Pregnant and breast-feeding patients. Patient who were otherwise fulfilling all criteria of inclusion, but did not give consent.

Design outcomes

Primary

MeasureTime frame
Remnant AblationTimepoint: Six months followed by first dose of Radioiodine

Secondary

MeasureTime frame
NoneTimepoint: None

Countries

India

Contacts

Public ContactDr C S Bal

All India Institute of Medical Sciences (AIIMS)

dwivedi7@hotmail.com91-11-26593387

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026