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To compare the usefulness and side effects of Deflazacort and Prednisolone in Nephrotic syndrome in children

Deflazacort versus Prednisolone: Randomised controlled trial in treatment of children with Idiopathic Nephrotic Syndrome

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2011/12/002208
Enrollment
25
Registered
2011-12-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Idiopathic Nephrotic Syndrome

Interventions

Intervention1: Deflazacort: Deflazacort is a methyl oxazoline derivative of Prednisolone. It has lesser side effects of steroid with supposed equal efficacy. To be given orally as 2.4 mg per kg per da

Sponsors

Govt MultiSpeciality Hospital Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 25 patients of Idiopathic Nephrotic Syndrome

Exclusion criteria

Exclusion criteria: 1) Age less than 2 years and more than 12 years 2) cases of Acute Glomerulonephritis 3) Earlier diagnosed cases of Steroid resistant, steroid dependant, frequent relapsing Nephrotic syndrome 4) Cases of Secondary Nephrotic syndrome due to Hepatitis B and Collagen vascular diseases

Design outcomes

Primary

MeasureTime frame
1)Time taken to induce remission in both groups 2) Remission rate in both groups 3) Number of relapses on and off drugsTimepoint: During steroid treatment period and then 6 months of follow up

Secondary

MeasureTime frame
1) To compare mean weight gain in both groups 2) To compare mean weight-height ratio 3) To compare development of cushingoid symptoms in both groups 4) To compare development of hypertension and posterior capsular opacity in both groups 5) To compare steroid resistance rate in both groupsTimepoint: During steroid treatment period

Countries

India

Contacts

Public ContactDr Ravish Singhal

GMSH Sec 16 Chandigarh

ndhawan_6144@yahoo.com09815629496

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026