Health Condition 1: null- term neonates with perinatal asphyxia
Conditions
Interventions
Intervention1: Therapeutic hypothermia: After taking the informed written consent from the parents of the newborns fulfilling the inclusion criteria, allocation of participants to specific treatment g
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Inborn babies with : 1+2+3 + any one of 4 1. Gestational, age >= 37 weeks 2. ABG(umbilical cord or 1st postnatal hour pH = 12meq 3. Evidence of encephalopathy (THOMPSON SCORE >5) 4. Any one of the following i. APGAR ii. Evidence of fetal distress iii. Assisted ventilation for at least 10 min after birth iv. Evidence of any organ dysfunction v. History of acute perinatal event- intrapartum fetal distress, cord prolapse placental abruption ,uterine rupture, maternal trauma,cardiac arrest
Exclusion criteria
Exclusion criteria: i. Infants >6 hours of age at the time of randomisation ii. Major congenital abnormalities iii. If the baby does not establish spontaneous respiration by 20 minutes iv. outborn babies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of Total antioxidant status(TAS), Malondialdehyde (MDA)in both the groups.Timepoint: At birth and at 72 hours of age in both groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Death, neurological disability at discharge in both the groups Timepoint: followed up till discharge from hospital | — |
Countries
India
Contacts
Public ContactDr Vishnu Bhat
JIPMER
Outcome results
None listed