Efficacy of dexmedetomidine as an adjuvant to bupivacaine in spinal anesthesia for lower abdominal surgery

Clinical evaluation of dexmedetomidine as an adjuvant to bupivacaine in subarachnoid block for lower abdominal surgery:A randomized double blind controlled study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2011/12/002186

Enrollment

100

Registered

2011-12-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Conditions requiring lower abdominal surgery i.e. Inguinal hernia, Open appendicectomy

Interventions

Intervention1: Bupivacaine+Dexmeditomidine: 2.5ml 0.5%Hyperbaric Bupivacaine+0.5 Ml Distilled Water Containing 5 Microgram Dexmedetomedine, Single Dose Control Intervention1: Bupivacaine + Distilled W

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age: 30 to 60 years. 2.Sex: Male. 3.Patients posted for lower abdominal surgery; i. e. inguinal hernia repair and open appendicectomy. 4.Informed written consent for participation in study. 5.BMI 25 kg/m2.

Exclusion criteria

Exclusion criteria: 1. Uncontrolled or labile hypertension. 2. Contraindication to spinal anaesthesia. 3. Allergy to local anaesthetic or study drug. 4. Body mass index >25 kg/m2. 5. Patients taking any analgesics sedative or antihypertensive drugs. 6. Neurological disorders. 7. Psychiatric disorders. 8. Unco- operative patients.

Design outcomes

Primary

Measure	Time frame
Onset, Peak And Duration Of Sensory And Motor Block.Timepoint: 0 min, 1 min, 2min, 3min, 5min, 10min, 15min,20min, 30min, 45min, 60min, 75min, 90min, 105min, 120min,135min, 150min,165min, 180min, 210min, 240min, 270min, 300min, 330min, 360min(6 hours), 8 hours, 10hours, 12hours, 14hours, 16hours, 20hours and 24hours.	—

Secondary

Measure	Time frame
Post Operative Analgesia,Sedation And Complication If Any Withon 24 Hours Of Subarachnoid BlockTimepoint: 0 min, 1 min, 2min, 3min, 5min, 10min, 15min,20min, 30min, 45min, 60min, 75min, 90min, 105min, 120min,135min, 150min,165min, 180min, 210min, 240min, 270min, 300min, 330min, 360min(6 hours), 8 hours, 10hours, 12hours, 14hours, 16hours, 20hours and 24hours.	—

Countries

India

Contacts

Public ContactDrDCTripathi

Government medical college and sir takhtsinhji general hospital bhavnagar

drtripathi1961@yahoo.co.in09428408718

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026