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Evaluation of Probiotics In Prevention Of Fungal Infection (Candida) in Sick Children in ICU

Evaluation of Probiotics In Prevention Of Candidemia In Critically Ill Children â?? A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2011/11/002172
Enrollment
240
Registered
2011-11-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Sepsis

Interventions

Intervention1: Probiotic: Probiotic consists of Lactobacillus acidophilus, Lactobacillus. rhamnosum, Bifidobacterium longum, Bifidobacterium bifidum, Saccharomyces boulardii, Saccharomyces thermophilu

Sponsors

ICMR Applied for
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients admitted to PICU who has received broad spectrum antibiotics for a minimum of 48 hours

Exclusion criteria

Exclusion criteria: 1. Known immunodeficiency states 2. Immunosuppressive therapy 3. Child on prior antifungal therapy.

Design outcomes

Primary

MeasureTime frame
Growth of Candida in blood (Candidemia)Timepoint: Day 7 and 14—

Secondary

MeasureTime frame
1. Isolation of Candida in rectal swab (rectal colonization). 2. Isolation of Candida in urine (Candiduria) 3. Changes in innate and adaptive immune responseTimepoint: Day 7 and 14—

Countries

India

Contacts

Public ContactSunit Singhi

PGIMER

sunit.singhi@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026