Is vitamin B12 tablets as effective as vitamin B12 injections for the treatment of vitamin B12 deficiency?

Evaluation of etiological profile and comparison of efficacy of oral versus intramuscular vitamin B12 supplementation in subjects with vitamin B12 deficiency

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2011/11/002146

Enrollment

Registered

2011-11-18

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- vitamin B12 deficiency

Interventions

Intervention1: oral vitamin B12: oral vitamin B12 1000mcg once daily for three months Control Intervention1: intramuscular vitamin B12: intramuscular injections of vitamin B12 once daily for a week, f

Eligibility

Inclusion criteria

Inclusion criteria: All patients with documented vitamin B12 deficiency (serum vitamin B12 level who consent for the study

Exclusion criteria

Exclusion criteria: 1. Age less than 18years 2. Pregnant individuals 3. Renal failure 4. Special cases where parenteral B12 supplementation is mandatory (eg: those patients with severe neurological deficits, intestinal failure etc) 5. Already taking vitamin B12 supplements

Design outcomes

Primary

Measure	Time frame
serum vitamin B12 levelsTimepoint: three months after initiation of therapy	—

Secondary

Measure	Time frame
1.change in haemoglobin,mean corpuscular volume, serum homocysteine,clinical symptomsTimepoint: 3months	—

Countries

India

Contacts

Public ContactAshok Chacko

Christian Medical College, Vellore

chacko.ashok@gmail.com04162282148

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026