Health Condition 1: null- Admitted with a diagnosis of viral encephalitis
Conditions
Interventions
Intervention1: Probiotic: Streptococcus thermophilus
Bifidobacteria (B. longum, B. infantis, B. breve)
Lactobacillus plantarum
Lactobacillus delbrueckii subsp. bulgaricus
Lactobacillus acidophilus L
Sponsors
India Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosed with acute encephalitis: Clinical definition : Any person, of any age, admitted to hospital with encephalopathy (altered level of consciousness persisting for >24 h and including lethargy, irritability or a change in personality and behaviour) and >= 2 of the following : 1. Fever or history of fever (>=380 C) ; 2. seizures and/or focal neurological findings (with evidences of brain parenchymal involvement ) ; 3. CSF pleocytosis ( > 4 WBC/ ml) ; 4. Electroencephalogram findings compatible with encephalitis ; 5. Abnormal results of neuroimaging in keeping with encephalitis.
Exclusion criteria
Exclusion criteria: Patients having risk factor of small intestinal bacterial overgrowth other than cirrhosis - diabetes mellitus, history of abdominal surgery, immunomodulator drugs. Patients with active gastrointestinal bleed, intestinal obstruction or peritonitis or any other reason to withhold oral drug administration. Patients with advanced hepatocellular failure, renal failure and portal vein thrombosis Patients with suspected or proven rabies Diagnosed HIV positive or any other condition causing immune-deficiency Children with proven or suspected malignancies Evaluation and laboratory testing o Detailed
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportions of patients with a favorable outcome (pediatric cerebral performance category scale of 1-3) in each group at 3 months after dischargeTimepoint: 3 months after discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality in each group during hospital stay Adverse effects of therapy in both the groups Etiology of encephalitis in the whole population of enrolled patientsTimepoint: at discharge | — |
Countries
India
Contacts
Public ContactPratibha Singhi
Post Graduate Institute of Medical Education and Research
Outcome results
None listed