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Effect of two anesthetic agents on brain protection.

Evaluation of cerebroprotective effects of Isoflurane and Propofol anesthesia in patients undergoing neuroendoscopic procedures - S100B - endoscopy

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2011/11/002100
Enrollment
30
Registered
2011-11-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Intracranial pathology to be intervened endoscopically

Interventions

Intervention1: Propofol: Propofol is an intravenous anaesthetic agent Intervention2: Propofol: Propofol is an intravenous anesthetic agent and it is administered via peripheral vein.Its dose is titrat

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of ASA physical status I and II undergoing neuroendoscopic procedures will be enrolled for the study.

Exclusion criteria

Exclusion criteria: 1. ASA grades III and IV 2. Redo surgery

Design outcomes

Primary

MeasureTime frame
Levels of S-100B in patients undergoing neuroendoscopic surgery under isoflurane or propofol anesthesia.Timepoint: S100B would be assessed at - 1.Before induction of anesthesia [Baseline] 2. At the end of surgery 3. 24 hours postoperative—

Secondary

MeasureTime frame
1. Adverse effects such as hypertension or hypotension, bradycardia or tachycardia, rhythm disturbances. 2. Clinical condition at discharge, as assessed by Glasgow outcome score (GOS) Timepoint: 1. Postoperative period 2. hospital dishcarge—

Countries

India

Contacts

Public ContactHemanshu Prabhakar
prabhakarhemanshu@rediffmail.com9868398205

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026