Clinical and immunological response to dahi "curd" in severely malnourished children

Clinical and immunological response to probiotics and nutritional rehabilitation in severely malnourished children.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2011/10/002091

Enrollment

Registered

2011-10-27

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Severely malnourished children between 2 to 5 year of age

Interventions

Intervention1: probiotic supplementation: 180 gm of probiotic dahi for 15 days Control Intervention1: No probiotic: standard diet without probiotic dahi"CURD" supplementation

Eligibility

Inclusion criteria

Inclusion criteria: Severely malnourished children. As per WHO classification (Weight for height Height for age <85%)

Exclusion criteria

Exclusion criteria: Children with milk product allergy,known immunodeficiency,onimmunosuppressive therapy,requiring parenteral alimentation and those with chronic systemic disease

Design outcomes

Primary

Measure	Time frame
cytokines (IL-1, IL-6 and IL-10) and Absolute lymphocyte count (A.L.C), T and B cell subpopulation (CD3, CD4, CD8, CD19, CD56+ cells)in probiotic supplemented and non supplemmented groups.Timepoint: IL-1, IL-6 and IL-10 day1,day 15, 6 wks A.L.C with T, B cell day 1 , 6 wks. (CD3, CD4, CD8, CD19, CD56+ cells) IL-1, IL-6 and IL-10 day1,day 15 , 6 wks Absolute lymphocyte count with T and B cell day 1 and at 6 weeks alongwith (CD3, CD4, CD8, CD19 and CD56+ cells) in probiotic supplemented and non supplemented at day 1 and at 6 Weeks.	—

Measure

Time frame

cytokines (IL-1, IL-6 and IL-10) and Absolute lymphocyte count (A.L.C), T and B cell subpopulation (CD3, CD4, CD8, CD19, CD56+ cells)in probiotic supplemented and non supplemmented groups.Timepoint: IL-1, IL-6 and IL-10 day1,day 15, 6 wks A.L.C with T, B cell day 1 , 6 wks. (CD3, CD4, CD8, CD19, CD56+ cells) IL-1, IL-6 and IL-10 day1,day 15 , 6 wks Absolute lymphocyte count with T and B cell day 1 and at 6 weeks alongwith (CD3, CD4, CD8, CD19 and CD56+ cells) in probiotic supplemented and non supplemented at day 1 and at 6 Weeks.

—

Secondary

Measure	Time frame
significant improvement in weight for height following nutritional rehabilitation in probiotic supplementation group, with no improvement in height for age.Timepoint: Day 1,Day 15 and at 6 to 8 wk	—

Countries

India

Contacts

Public ContactSunil gomber

ucms and gtb hospital,

archana425@gmail.com09958902058

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026