study the effectiveness of dexmedetomidine, a drug,given before start of surgery by anesthetist, in preventing increase in blood pressure and pulse rate which generally occurs at that time and can result in dangerous arrhythmias and heart attack

DEXMEDETOMIDINE AS AN ADJUNCT TO ANESTHETIC INDUCTION TO ATTENUATE HEMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOING SURGICAL PROCEDURES UNDER GENERAL ANESTHESIA

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2011/10/002046

Enrollment

100

Registered

2011-10-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- surgery under general anesthesia

Interventions

Intervention1: DEXMEDETOMIDINE as premedecation: Intravenous infusion(4 microgam/ml) for 10 min. total dose 1 microgram/kg. given once Control Intervention1: Normal saline: Normal Saline (0.9%) for 1

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with ASA grade 1 and 2 2.Patients of age group 18 to 55 years of either sex undergoing surgery under general anesthesia 3.Patients willing to give written and informed consent

Exclusion criteria

Exclusion criteria: 1.Patients refusal 2.Major organ dysfunction 3.Patients on medications like hypnotics, narcotic analgesics, α2 agonists, calcium channel blockers, β blockers 4.Patients with anticipated difficult intubation 5.Patients intubated after more than 1 attempt or more than 20 seconds 6.Patients with impaired LFT/RFT 7.Patients with ASA grade 3, 4, 5 8.Deaf and dumb patients 9.Patients with respiratory and cardiac disease 10.Patients having known allergy to anesthetic agents used in study 11.Psychiatric patients

Design outcomes

Primary

Measure	Time frame
change in systolic, diastolic and mean blood pressure, pulse rate, oxgen saturation compared to baseline at various points before and after intubation compared to baselineTimepoint: 5 , 10 ,13,14(just after intubation),15,18,20,25 min after start of drug infusioon and baseline parameters	—

Secondary

Measure	Time frame
complications like bradycardia , hypotention etcTimepoint: intraoperative( time period may vary and immediate post operative till 10 min after extubation	—

Countries

India

Contacts

Public Contactrishabh kumar

swai man singh medical college jaipur

cool_rishu@hotmail.com09694580547

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026