Health Condition 1: null- Closed Fracture with Open reduction and internal fixation
Conditions
Interventions
Intervention1: Prophylatic Antibiotics- Cefurixime: Pre-Operation 1.5 Gms,Post operation 750 mg BD
Control Intervention1: Prophylatic Antibiotics- Cefurixime and Amikacin: conventional long courses of
Sponsors
Indian Council Of Medical Research
Indian Council Of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Patients of either sex, aged 18 years or more, who were scheduled for open reduction and internal fixation of closed fractures and was willing and able to give informed consent will be recruited to the trial. Only those patients suffering from closed fractures of limbs (upper/ lower) were included in the study.
Exclusion criteria
Exclusion criteria: The following patients will be excluded from the study: 1. Patients undergoing simple percutaneous kirschner wire fixation or external fixation. 2. Known hypersensitivity to cephalosporins, 3. Antimicrobial use or symptoms of infection in the week before surgery. 4. Pregnant females 5. Patients on immunosuppressive treatment 6. Patients suffering from compound fractures. 7. Patients suffering from multiple fractures. 8. Patients having underlying illnesses like diabetes, coronary artery disease, hypertension, chronic obstructive airway disease, any other chronic ailment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| No Infection at surgical siteTimepoint: 2 Months Followes | — |
Secondary
| Measure | Time frame |
|---|---|
| Cost effectivenessTimepoint: Two years | — |
Countries
India
Contacts
Public ContactDr Purva Mathur
Outcome results
None listed