Comparison of two drugs in pre-operative preparation of Pheochromocytoma

Comparative study of pre-operative blockade using Phenoxybenzamine vs. Prazosin efficacy ( intra- and post-operative hemodynamic changes) and safety profile in Pheochromocytoma

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2011/09/002019

Enrollment

Registered

2011-09-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Pheochromocytoma

Interventions

Control Intervention1: Phenoxybenzamine (an alpha blocker): Dose- 10 mg to 80 mg PO per day for 10-15 days depending on effect of alpha blockade Control Intervention2: Prazosin (an alpha blocker): Dos

Eligibility

Inclusion criteria

Inclusion criteria: All patients with biochemically proven Pheochromocytoma/functional paraganglioma that will undergo surgery for removal of tumor

Exclusion criteria

Exclusion criteria: Those patients of pheochromocytoma who will not undergo surgery due to any reasons

Design outcomes

Primary

Measure	Time frame
Assessment of strength and weaknesses of both drugs in terms of- 1. Preoperative time taken for adequate preparation and safety profile 2. Number of intra-operative and post-operative fluctuations in blood pressure and heart rate 3. Occurrence of arrythmia- pre-, intra- or postoperatively 4. Time taken for restoration of normal haemodynamics in post-operative periodTimepoint: End point of study 1. Till restoration of normal haemodynamics in post-operative period	—

Measure

Time frame

Assessment of strength and weaknesses of both drugs in terms of- 1. Preoperative time taken for adequate preparation and safety profile 2. Number of intra-operative and post-operative fluctuations in blood pressure and heart rate 3. Occurrence of arrythmia- pre-, intra- or postoperatively 4. Time taken for restoration of normal haemodynamics in post-operative periodTimepoint: End point of study 1. Till restoration of normal haemodynamics in post-operative period

—

Secondary

Measure	Time frame
NILTimepoint: Not Applicable	—

Countries

India

Contacts

Public ContactProf SK Mishra

Department of Endocrine Surgery

drriteshagrawal@rediffmail.com8004904651

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026