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Comparison Of Efficacy Of Different Treatment Regimens In Pulmonary Artery Hypertension Secondary To Lung Disease And/Or Hypoxia

comparison of efficacy Of different treatment regimens In pulmonary artery hypertension secondary to lung disease and/or hypoxia.

Status
Recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2011/09/001992
Enrollment
45
Registered
2011-09-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Pulmonary artery hypertension secondary to lung disease and/or hypoxia

Interventions

Intervention1: Bosentan and sildenafil: Bosentan will be started at 62.5mg BD for 4 weeks and then increased to 125mg BD. Sildenafil will be started at 20mg OD and then increased to 20mg TDS if there

Sponsors

Dr SK Sharma
Lead Sponsor
Dr ANANT MOHAN Assoc Prof Deptt of Medicine AIIMS
Collaborator
Dr GC KHILNANI Prof Deptt of Medicine AIIMS
Collaborator
Dr SANDEEP SINGH Asstt Prof Deptt of Cardiology AIIMS
Collaborator
Dr SANJEEV SINHA Assoc Prof Deptt of Medicine AIIMS
Collaborator
Dr V SREENIVAS Assoc Prof Deptt of Biostatistics AIIMS
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ? Pulmonary artery hypertension diagnosed by doppler echocardiography as mean pulmonary artery pressure 25 mmHg (done in department of cardiology, AIIMS) ? Age more than 18 years ? Pulmonary artery hypertension due to hypoxia, either chronic obstructive airway disease or diffuse pulmonary lung disease ? Willing to consent to participate in the trial ? WHO functional class I,II, III

Exclusion criteria

Exclusion criteria: ? WHO functional class IV ? Patient participating in any other trial ? Concomitant coronary artery disease ? Nitrate intake ? Liver dysfunction ? Pregnancy and lactation

Design outcomes

Secondary

MeasureTime frame
Following parameters at 3 months ? WHO functional classification ? 6 minute walk test ? Pulmonary function test ? Visual analog scale for dyspnea ? Echocardiography measuring pulmonary artery pressure ? Biochemical markers and at 6 months Timepoint: 3 months—

Primary

MeasureTime frame
Following parameters at 6 months ? WHO functional classification ? 6 minute walk test ? Pulmonary function test ? Visual analog scale for dyspnea ? Echocardiography measuring pulmonary artery pressure Timepoint: Following parameters at 6 months ? WHO functional classification ? 6 minute walk test ? Pulmonary function test ? Visual analog scale for dyspnea ? Echocardiography measuring pulmonary artery pressure—

Countries

India

Contacts

Public ContactDr S K Sharma

AIIMS

sksharma@aiims.ac.in01126594415

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026