Health Condition 1: null- Patients with acute STEMI who are to be treated with primary PCI/pharmacoinvasive therapy within 12 hours of symptoms onset will be included.
Conditions
Interventions
Intervention1: facilitated Percutaneous coronary intervention: Early fibrinolytic treatment with Tenecteplase (TNK) and additional antiplatelet and antithrombin therapy followed by catheterization wit
Sponsors
STEMI India Charitable Trust
Eligibility
Inclusion criteria
Inclusion criteria: All patients included in the study should satisfy the following criteria. 1.Adults 18 to 75 years of age complaining of chest pain, discomfort and/or indications of STEMI requiring either primary PCI or tenecteplase facilitated PCI will be included in the study. 2.Patients presenting with the onset of symptoms within 12 hours. 3.ECG including right ventricular leads (V4R) indicative of an acute STEMI (ST elevation will be measured from the J point scale; 1 mm per 0.1 mV greater than or equal to 2 mm ST elevation across 2 contiguous precordial leads (V1-V6) or leads I and aVL for a minimum combined total of greater than or equal to 4 mm ST elevation) OR Greater than or equal to 3mm ST elevation in 2 contiguous inferior leads (II, III, aVF) for a minimum combined total of greater than or equal to 6 mm ST elevation. 4.Subjects / LAR or impartial witness (if applicable) must be able to understand and provide their consent in the informed consent form.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria will not be enrolled into the study. 1.Previous enrollment in this study or treatment with the investigational drug or participating in any other study in the past 30 days 2.Patients who are unwilling to participate in the study or sign the informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Following are the Primary Endpoints: Death and reinfarction Death maybe due to cardio vascular and non-cardio vascular reasons. Death due to cardio vascular reasons may include: 1)Reinfarction 2)Cardiogenic Shock 3)Cardiac failure Death due to non cardio vascular reasons may include 1)Procedure related injury 2)Others Timepoint: Nil | — |
Secondary
| Measure | Time frame |
|---|---|
| Following are the Secondary Endpoints: 1)Nonintracranial hemorrhage (total, major, minor and blood transfusions) 2)Intracranial hemorrhage Timepoint: Nil | — |
Countries
India
Contacts
Public ContactMullasari Ajit sankardas
Kovai Medical Center and Hospital
Outcome results
None listed