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TO EVALUATE THE EFFICACY OF TRANEXAMIC ACID(drug used to reduce blood loss in various surgeries) IN REDUCING PERIOPERATIVE BLOOD LOSS AND ITS EFFECT ON SHUNT PATENCY IN LIENO RENAL SHUNT SURGERIES (a type of surgery done to reduce the pressure in veins connecting liver and intestine)

TO EVALUATE THE EFFICACY OF TRANEXAMIC ACID IN REDUCING PERIOPERATIVE BLOOD LOSS AND ITS EFFECT ON SHUNT PATENCY IN LIENO RENAL SHUNT SURGERIES: A PROSPECTIVE, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2011/08/001940
Enrollment
32
Registered
2011-08-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients scheduled for Lieno Renal Shunt surgeries

Interventions

Intervention1: tranexamic acid: Patients had been administered bolus injection of TXA 10 mg/kg (0.1 mL/kg) intravenously over half an hour at the time of induction, followed by an infusion @ 1 mg/kg/h

Sponsors

Suryakumar Narayanasamy
Lead Sponsor
Ravindar Kumar Pandey
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for LR Shunt surgeries were included in the study if they were more than 18 years of age and less than 65 years of age, ASA physical status ? I-III.

Exclusion criteria

Exclusion criteria: 1 Bleeding diathesis / dyscrasias (hematopoietic malignancies) or any drug altering coagulation status like antiplatelet drugs (aspirin), warfarin, on NonSteroidal Anti Inflammatory Drugs (NSAIDs) prior to surgery 2 Deranged Coagulation parameters 3 Patients with renal disorder 4 Chronic liver disease (Child B or higher degree) including cirrhotic liver disease 5 Ophthalmic problem (retinal involvement) 6 History of thromboembolic events (acute coronary syndrome, Cerebro Vascular Accidents [CVA], deep vein thrombosis) 7 Pregnancy 8 Sepsis 9 H/o seizures/epilepsy 10 Allergy to Tranexamic acid and 11 Patient refusal

Design outcomes

Primary

MeasureTime frame
Total Bleeding - intraoperative, postoperative at 6 hours, 24 hours, till removal of drains.Timepoint: intraoperative,postoperative at 6 hours, 24 hours (by total blood in all drains), till removal of drains.—

Secondary

MeasureTime frame
D-dimer, Fibrinogen, PT, aPTTTimepoint: at preoperative, intraoperatively at 2 hours and postoperatively at 24 hours.;Doppler study for assessing leinorenal shunt patencyTimepoint: at 24 hours and 3 months;Total PRBC, PRP, FFP, plasma transfusedTimepoint: intraoperatively, postoperatively in 24 hours, till removal of drains—

Countries

India

Contacts

Public ContactSuryakumar Narayanasamy

All India Institute of Medical Sciences

trips22003@yahoo.co.in9868397817

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026