Health Condition 1: null- To determine the effectiveness of prophylactic oral application of chlorhexidine in decreasing the incidence of ventilator associated pneumonia in mechanically ventilated neonates
Conditions
Interventions
Intervention1: Chlorhexidine (chlorhexidine gluconate 0.2% w/v with no other ingredients): 1 ml of chlorhexidine (chlorhexidine gluconate 0.2% w/v with no other ingredients) on the mucosa of the oral
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: All neonates intubated for mechanical ventilation
Exclusion criteria
Exclusion criteria: 1.Suspected or proven lung malformations 2.Congenital lethal malformations 3.Refusal of consent 4.Investigator not available 5.Oral malformations (cleft palate and Pierre-Robin Syndrome) where application of chlorhexidine will be difficult. 6. Conditions whose radiological appearance will make VAP assessment difficult (CHD, HMD with white out lung, pleural effusion). CHD is defined clinically as presence of any of the given features : systolic murmur gr- III or more, diastolic murmur, cyanosis without apparent respiratory cause, antenatally diagnosed CHD, arrhythmia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Episode of VAP (ventilator associated pneumonia) per person-ventilation daysTimepoint: Episode of VAP (ventilator associated pneumonia) per person-ventilation days were recorded till 48 hours after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Incidence of VAP 2.Qualitative analysis of oral and tracheal micro flora 3.Percentage of patients developing local or systemic adverse drug reactions to chlorhexidine Timepoint: Episode of VAP (ventilator associated pneumonia) per person-ventilation days were recorded till 48 hours after extubation and others were noted down while the patient received oral chlorhexidine application | — |
Countries
India
Contacts
Public ContactDr Sourabh Dutta
PGIMER
Outcome results
None listed