A clinical trial to study the effects of two preparations, Ketamine with normal saline and only normal saline in patients receiving general anaesthesia.

Evaluation of efficacy of nebulized Ketamine for the relief of postoperative sore throat in adult patients- a randomized, double-blind controlled trial. - none

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2011/07/001902

Enrollment

Registered

2011-07-19

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: null- Postoperative sore throat

Interventions

Intervention1: Ketamine: Ketamine 50 mg (1.0 ml) with 4.0 ml of normal saline nebulization of total 5.0 ml will be prepared by a staff nurse not part of study and patients will receive nebulization f

Eligibility

Inclusion criteria

Inclusion criteria: American society of anesthesiologist (ASA) I?II General anaesthesia with endotracheal intubation

Exclusion criteria

Exclusion criteria: Patients with a history of preoperative sore throat oral surgeries asthma chronic obstructive pulmonary disease (COPD) raised intracranial pressure Mallampati grade 2 known allergies to study drug recent NSAID medication those who required more than one attempt at intubation

Design outcomes

Primary

Measure	Time frame
Assesment of sore throat in adult patients undergoing surgery under general anaesthesia at pre nebulization (T0), pre induction (T1),immediate recovery (T2),two hours (T3), four hours (T4), six hours (T5),eight hours (T6),twelve hours(T7) and twenty four hours (T8) post operatively and graded on a four-point scale (0?3).Presuming the incidence of postoperative sore throat to be 65%, to show a 50% reduction in the incidence.Timepoint: Outcome Name: Postoperative sore throat at pre nebulization (T0), pre induction (T1),immediate recovery (T2),two hours (T3), four hours (T4), six hours (T5),eight hours (T6),twelve hours(T7) and twenty four hours (T8) post operatively.	—

Measure

Time frame

Assesment of sore throat in adult patients undergoing surgery under general anaesthesia at pre nebulization (T0), pre induction (T1),immediate recovery (T2),two hours (T3), four hours (T4), six hours (T5),eight hours (T6),twelve hours(T7) and twenty four hours (T8) post operatively and graded on a four-point scale (0?3).Presuming the incidence of postoperative sore throat to be 65%, to show a 50% reduction in the incidence.Timepoint: Outcome Name: Postoperative sore throat at pre nebulization (T0), pre induction (T1),immediate recovery (T2),two hours (T3), four hours (T4), six hours (T5),eight hours (T6),twelve hours(T7) and twenty four hours (T8) post operatively.

—

Secondary

Measure	Time frame
Any other side effectsTimepoint: 06 months	—

Countries

India

Contacts

Public ContactDr Vanita Ahuja

Government Medical College and Hospital, Sector-32, Chandigarh

vanitaanupam@yahoo.co.in9815496989

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026