Health Condition 1: null- Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Intervention1: Doxycycline: It is an antibiotic, a synthetic tetracycline derivative already available in the market.
Intervention2: Doxycycline: It is an antibiotic,a synthetic tetracycline derivati
Sponsors
Dr Parthasarathi Bhattacharyya
Institute of Pulmocare and Research
Eligibility
Inclusion criteria
Inclusion criteria: Informed written consent being given Male and female patients aged 40-70 years Has been on optimum pharmacotherapy for COPD COPD severity diagnosed by GOLD criteria No significant occupational history FEVI 30-50%predicted; FEVI/FVC less than70% Non pregnant, non lactating woman
Exclusion criteria
Exclusion criteria: History of exacerbation in past 1 month History of Doxy allergy Having any obvious contraindication for Doxycycline Unable to meet the demand of the protocol for any reason Significant abnormality in liver or renal or other organ function Feature of chronic congestive cardiac failure (supported by echocardiography any other concomitant lung disease (significant as per PI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in both pre and post bronchodilator FEVITimepoint: As and when atleast 30 patients will take doxycycline for at least 6 months and shall have at least one repeat spirometry done in a real world situation. | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactParthasarathi Bhattacharyya
Consultant
Outcome results
None listed