Health Condition 1: null- neonatal seizures
Conditions
Interventions
Intervention1: IV LEVETIRACETAM
: Intervention Agent- IV Levetiracetam is given at loading dose of 60 mg/kg followed by maintenance at 30mg/kg/day 12th hrly.
Control Intervention1: Intervention -Levet
Sponsors
DR AMIT UPADHYAY
Eligibility
Inclusion criteria
Inclusion criteria: 1.patients with clinically apparent seizures with perinatal asphyxia, and HIE With weight greater than 2 kg. 2. patient with seizures not responding to treatment of hypoglycemia, hypocalcemia.
Exclusion criteria
Exclusion criteria: 1.Serum creatinine greater than 1.2 at enrollment or greater than 2 at any time. 2.Major congenital malformations 3.Sick neonates with significant respiratory distress requiring assisted ventilation,ionotropic support,symptomatic hypocalcemia/hypoglycemia,renal/cardiac failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical control of seizuresTimepoint: 12 hrs from last episode of seizures | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of electrical seizures after control of clinical seizuresTimepoint: At 3 months and at 6 months of age.;Neurological examinationTimepoint: At time of discharge, at 3 months and at 6 months.;Safety profile of levetiracetam.Timepoint: At 3 and 6 months of age;Time taken to control clinical seizuresTimepoint: At the time of admission | — |
Countries
India
Contacts
Public ContactDr AMIT UPADHYAY
Outcome results
None listed