Health Condition 1: null- Proteinuria, Kidney disease
Conditions
Interventions
Intervention1: Telmisartan: 20 mg/day oral will be increased upto 80 mg/day for 24 weeks
Intervention2: Olmesartan: 20 mg/day oral, will be increased upto 40 mg/day for 24 weeks
Intervention3: losart
Sponsors
Nil
Eligibility
Inclusion criteria
Inclusion criteria: Patients of either gender above 18yrs of age Willing to give written informed consent Proteinuria more than 1000mg/day confirmed on two consecutive 24 hr urine samples and with serum creatinine less than 2 mg/dl
Exclusion criteria
Exclusion criteria: Pregnancy or planned childbearing during specified study period Serum creatinine more than 2 mg/dl and/or potassium more than 4.8mg/dl Preexisting severe hepatic dysfunction Uncontrolled hypertension (>160/100 mmHg) Uncontrolled diabetes (random blood sugar >300) Hemodynamic instability (systolic BP <90mmHg, NYHA III-IV CCF or other condition as judged by physician) Bilateral renal artery stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ProteinuriaTimepoint: 2weeks, 4weeks, 8weeks, 12weeks, 24weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of episodes of hypotension, hyperkalemia and increase in creatinine of more than 0.3mg/dlTimepoint: day 4, day 7, 2 weeks, 4weeks,8weeks, 12 weeks, 24 weeks | — |
Countries
India
Contacts
Public ContactTUKARAM E JAMALE
Senior Resident
Outcome results
None listed