Health Condition 1: null- PATIENTS WITH CHRONIC PANCREATITIS
Conditions
Interventions
Intervention1: Intervention includes antioxidans and placebo includes starch: The antioxidant supplementation includes daily doses of 600 microgm organic selenium, 0.54 g vitamin C, 9000 IU beta-carot
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with chronic pancreatitis willing to come at 3 monthly interval for 1 yr will be included in the study. 2. Patients with Chronic Pancreatitis with onset of symptom ie pain of less than equal to 3yrs for non diabetics and diabetics with any duration of disease.
Exclusion criteria
Exclusion criteria: 1. Patients who have received in the preceding 3 months or taking at present antioxidants will be excluded. 2. Patients who have had an intervention earlier in the form of decompressive therapy i.e. surgery or endoscopic sphincterotomy/ stenting or lithotripsy for pancreatic calculi. 3. Patients with systemic conditions such as liver disease, chronic renal failure, malignancy, hypertension, and pregnancy that might affect the antioxidant status and oxidative stress levels will be excluded. 4. Patients with complications such as symptomatic pseudocyst, bile duct obstruction, pancreatic abscess and pancreatic cancer 5. Patients not giving consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome 1. Improvement in beta cell function 2. Improvement of exocrine function 3. Improvement in markers of fibrosis Timepoint: 0,3,6 and 9 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reduction in pain and improvement in quality of life 2. Change in inflammatory markers 3. Improvement in nutritional status 4. Increase in the markers of antioxidant defense and decrease in parameters of oxidative stress 5. Change in the markers of oxidative stress and antioxidant status with and without continuation of supplementation Timepoint: 0,3,6 and 9 months | — |
Countries
India
Contacts
Public ContactDR ANOOP SARAYA
Outcome results
None listed