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A study to see the effect of antioxidants(vitamins and minerals that protect our cells) on scarring of the pancreas in patients with chronic pancreatitis

Effect of antioxidant supplementation on progression of pancreatic fibrosis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2011/05/001747
Enrollment
60
Registered
2011-05-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients of chronic pancreatitis

Interventions

Intervention1: The antioxidant supplementation will be given as capsules of betamoreG . The antioxidant supplementation will include daily doses of 600ug organic selenium,0.54g vit C, 9000 IU b-carot

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All the treatment naïve patient with Chronic Pancreatitis

Exclusion criteria

Exclusion criteria: 1. Complications like pseudocyst, pancreatic abscess, pseudoaneurysm, pancreatic fistula 2. Comorbid conditions like liver diseases,renal failure,pulmonary fibrosis. 3. Patient with adenocarcinoma of pancreas, acute on chronic pancreatitis. 4. Pregnant and lactating female 5. Age less than 12 years 6. Inability to give informed consent

Design outcomes

Primary

MeasureTime frame
Surrogate markers of pancreatic fibrosis: TGF-beta 1,PDGF, fibronectin and pro-collagen IIITimepoint: at baseline and 3 months of intervention—

Secondary

MeasureTime frame
Markers of oxidative stress: TBARS, Serum SOD Marker of antioxidant capacity or defense: Total glutathione, Ferric Reducing Assay of Plasma (FRAP) Timepoint: at baseline and 3 months after intervention—

Countries

India

Contacts

Public ContactDr Anoop Saraya
anoopgetrial@yahoo.com011-26593294

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 23, 2026