Health Condition 1: null- Active distal ulcerative colitis
Conditions
Interventions
Intervention1: Curcumin (NCB02): Each curcumin enema contained 140 mg of curcumin dissolved in 20 ml of water.
Patients were advised to take the enema preparation in the night prior to sleep. All the
Sponsors
Dr Vinnet Ahuja
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients 2. Mild-to-moderately active proctitis and proctosigmoiditis (Ulcerative Colitis Disease Activity Index [UCDAI] score, 3-9), with endoscopic disease extent up to 25 cm from the anal verge 3. Patients receiving mesalamine if the dose is stable for more than 8 weeks
Exclusion criteria
Exclusion criteria: 1. Patients receiving rectal mesalamine or steroids during last 4 weeks 2. Disease extent more than proctosigmoiditis, evidence of severe disease (UCDAI more than 10) 3. Steroid initiation/dose escalation within the past 2 weeks, 4. Azathioprine initiation in past 6 months or change in dose of azathioprine in last 3 months. 5. History of Patients started on mesalamine in the past 8 weeks. 6. Patients requiring hospitalization and imminent need for surgery 7. Lactating and pregnant women 8. Patients received any investigational medicines within 3 months 9. Patients with significant hepatic, renal, endocrine, respiratory, neurologic, or cardiovascular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure was improvement in activity of UC. This was defined as a decrease in the UCDAI by equal or more than 3 from baselineTimepoint: 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures were proportion of patients achieving remission and mucosal healingTimepoint: 8 week | — |
Countries
India
Contacts
Public ContactDr Vineet Ahuja
Outcome results
None listed